1494 Results for "

Melampodium divaricatum (Rich.) DC.

" in MedChemExpress (MCE) Product Catalog:
Products (1494)

1494 Results for "Melampodium divaricatum (Rich.) DC." in MCE Product Catalog:

141
Hoechst 33342
Hoechst 33342
0 Images
141 Publications Verification
Cat. No.: HY-15559
CAS No.: 23491-52-3
Purity:  99.94%
Synonyms: bisBenzimide H 33342; HOE 33342
Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
141
Hoechst 33342 trihydrochloride
Hoechst 33342 trihydrochloride
0 Images
141 Publications Verification
Cat. No.: HY-15559A
CAS No.: 875756-97-1
Purity:  99.81%
Synonyms: bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride
Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
116
Nile Red
Nile Red
0 Images
116 Cited Publications
Cat. No.: HY-D0718
CAS No.: 7385-67-3
Synonyms: Nile Blue A oxazone; Phenoxazone 9
Nile red (Nile blue oxazone) is a lipophilic stain. Nile red has environment-sensitive fluorescence. Nile red is intensely fluorescent in a lipid-rich environment while it has minimal fluorescence in aqueous media. Nile red is an excellent vital stain for the detection of intracellular lipid droplets by fluorescence microscopy and flow cytof uorometry. Nile red stains intracellular lipid droplets red. The fluorescence wavelength is 559/635 nm .
22
Hoechst 33258 trihydrochloride
Hoechst 33258 trihydrochloride
0 Images
22 Cited Publications
Cat. No.: HY-15558A
CAS No.: 23491-45-4
Purity:  99.51%
Synonyms: bisBenzimide H 33258 trihydrochloride; H 33258 trihydrochloride
Hoechst 33258 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
22
Hoechst 33258
Hoechst 33258
0 Images
22 Cited Publications
Cat. No.: HY-15558
CAS No.: 23491-44-3
Purity:  99.11%
Synonyms: bisBenzimide H 33258; H 33258
Hoechst 33258 is a blue to blue-green fluorescent live cell dye that can label DNA. Hoechst 33258 can specifically bind to the minor groove of DNA (and tends to bind to A/T-rich DNA), resulting in a significant increase in fluorescence intensity. Hoechst 33258 can cross the cell membrane and cause changes in DNA structure, such as G2/M phase arrest. Hoechst 33258 can bind to live or fixed cells, and the fluorescence intensity increases with increasing solution pH. As a DNA-specific probe, Hoechst 33258 can be used to detect DNA content, analyze cell cycle, etc. The excitation wavelength of Hoechst 33258 is 350-365 nm, and the emission wavelength is 460-490 nm .
18
SGI-1027
SGI-1027
0 Images
18 Cited Publications
Cat. No.: HY-13962
CAS No.: 1020149-73-8
Purity:  99.77%
Target:  

DNA Methyltransferase Apoptosis

Research Areas:  

Cancer

SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.
17
SRPIN340
SRPIN340
0 Images
17 Cited Publications
Cat. No.: HY-13949
CAS No.: 218156-96-8
Purity:  99.62%
Synonyms: SRPK inhibitor
Target:  

SRPK Virus Protease

Research Areas:  

Cancer

SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1.
13
SPHINX31
SPHINX31
0 Images
13 Cited Publications
Cat. No.: HY-117661
CAS No.: 1818389-84-2
Target:  

SRPK VEGFR

Research Areas:  

Cardiovascular Disease Cancer

SPHINX31 is a potent and selective SRPK1 inhibitor, with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 also decreases the mRNA expression of pro-angiogenic VEGF-A165a isoform. SPHINX31 can be used to research neovascular eye disease .
13
Hyaluronidase, Ovine testes
Hyaluronidase, Ovine testes
0 Images
13 Cited Publications
Cat. No.: HY-108903A
CAS No.: 37326-33-3
Purity:  95.00%
Target:  

Glycosidase Biochemical Assay Reagents

Research Areas:  

Endocrinology

Hyaluronidase, Ovine testes is an endoglycosidase. Hyaluronidase, Ovine testes specifically degrades Hyaluronic acid (HY-B0633A) and Chondroitin sulfate (HY-B2162) by hydrolyzing β-glycosidic bonds in acidic mucopolysaccharides. Hyaluronidase, Ovine testes disperses follicular cells during fertilization by breaking down the hyaluronic acid-rich cumulus. Hyaluronidase, Ovine testes can be used in the study of fertility-related diseases .
11
Diminazene aceturate
Diminazene aceturate
0 Images
11 Cited Publications
Cat. No.: HY-12404
CAS No.: 908-54-3
Purity:  99.16%
Synonyms: Diminazene diaceturate
Target:  

Parasite Angiotensin-converting Enzyme (ACE)

Research Areas:  

Infection Inflammation/Immunology

Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties .
11
ACBI1
ACBI1
0 Images
11 Cited Publications
Cat. No.: HY-128359
CAS No.: 2375564-55-7
Purity:  99.92%
Target:  

PROTACs SWI/SNF Complex Apoptosis

Research Areas:  

Cancer

ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis .
11
Ligustrazine hydrochloride
Ligustrazine hydrochloride
0 Images
11 Cited Publications
Cat. No.: HY-N0935
CAS No.: 76494-51-4
Synonyms: Chuanxiongzine hydrochloride; Tetramethylpyrazine hydrochloride
Category:  

Alkaloids Other Alkaloids Other Diseases Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields

Target:  

Reactive Oxygen Species (ROS) Akt NO Synthase Aminotransferases (Transaminases)

Ligustrazine hydrochloride is an orally active, blood-brain barrier-permeable alkaloid. It can be isolated from Ligusticum striatum DC. Ligustrazine hydrochloride reduces ROS, upregulates the levels of p-Akt/Akt and p-eNOS/eNOS, and decreases ALT and AST. It inhibits glutamate excitotoxicity, calcium overload, oxidative stress, ischemia-reperfusion injury and atherosclerotic plaque progression, enhances synaptic plasticity, and improves neurological function, cerebral infarct volume and brain water content. Ligustrazine hydrochloride possesses anti-inflammatory, antioxidant, lipid-lowering, endothelial protective and hepatoprotective activities. It can be used in studies related to ischemic stroke, cerebral ischemia-reperfusion injury and atherosclerosis .
9
Phen-DC3 Trifluoromethanesulfonate
Phen-DC3 Trifluoromethanesulfonate
0 Images
9 Cited Publications
Cat. No.: HY-15594A
CAS No.: 929895-45-4
Purity:  98.99%
Synonyms: Phen-DC3 Triflate
Target:  

G-quadruplex

Research Areas:  

Cancer

Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively.
8
LY 345899
LY 345899
0 Images
8 Cited Publications
Cat. No.: HY-101943
CAS No.: 10538-99-5
Purity:  ≥98.0%
Target:  

Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Research Areas:  

Cancer

LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1 .
8
PROTAC FAK degrader 1
PROTAC FAK degrader 1
0 Images
8 Cited Publications
Cat. No.: HY-119932
CAS No.: 2301916-69-6
Purity:  99.25%
Target:  

PROTACs FAK Akt

Research Areas:  

Cancer

PROTAC FAK degrader 1 (Compound PROTAC-3) is a selective and effective degrader of Fak PROTAC with a DC50 of 3.0 nM. PROTAC FAK degrader 1 reduces the ability of cancer cells to migrate and invade. PROTAC FAK degrader 1 can be used in the study of tumor .
7
Hoechst 33258 analog 6
Hoechst 33258 analog 6
0 Images
7 Cited Publications
Cat. No.: HY-15631
CAS No.: 129244-66-2
Purity:  99.63%
Hoechst 33258 analog 6 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution (Ex/Em = 356/451 nm) .
6
DC661
DC661
0 Images
6 Cited Publications
Cat. No.: HY-111621
CAS No.: 1872387-43-3
Purity:  99.53%
Target:  

Autophagy Apoptosis

Research Areas:  

Cancer

DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity .
6
DC_AC50
DC_AC50
0 Images
6 Cited Publications
Cat. No.: HY-107636
CAS No.: 497061-48-0
Purity:  99.97%
Target:  

Apoptosis

Research Areas:  

Cancer

DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance .
6
PF-431396
PF-431396
0 Images
6 Cited Publications
Cat. No.: HY-10460
CAS No.: 717906-29-1
Purity:  99.74%
Target:  

Pyk2 FAK

Research Areas:  

Cancer

PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC50 values of 2 nM and 11 nM, respectively .
6
Vepdegestrant
Vepdegestrant
0 Images
6 Cited Publications
Cat. No.: HY-138642
CAS No.: 2229711-68-4
Purity:  99.60%
Synonyms: ARV-471
Target:  

PROTACs Estrogen Receptor/ERR

Research Areas:  

Cancer

Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
Assay Types